Nucleosomes restrict the occupancy of most transcription factors (TF) by reducing binding and accelerating dissociation, while a small group of TFs have high affinities to nucleosome-embedded sites and facilitate nucleosome displacement.To understand this process mechanistically, we investigated two Saccharomyces cerevisiae TFs, Reb1 and Cbf1.We sh
Introduction: Desmoid-type fibromatosis (DF) is a fibrous tumor characterized by low-grade malignant and easy invasive growth and high recurrence.High-intensity focused ultrasound (HIFU) therapy has been Fan Shop - CFL - Hats identified as a novel non-invasive approach for DF treatment; however, the ultrasonic energy generated by HIFU can cause ski
BACKGROUND:Current Chagas disease vector control strategies, based on chemical insecticide spraying, are growingly threatened by the emergence of pyrethroid-resistant Triatoma infestans populations in the Gran Chaco region of South America.METHODOLOGY AND FINDINGS:We have already shown that the entomopathogenic fungus Beauveria bassiana has the abi
Managing large-scale gatherings, such as global festivals, sporting events, Screen Protector and religious congregations, presents substantial challenges in ensuring crowd safety and control.Innovative frameworks are essential to address these complexities effectively.The Integrated Intelligent Crowd Control and Management (IICCM) framework combine